Boğaziçi University is seeking a highly motivated postdoctoral researcher to join a multidisciplinary research program focused on AI-driven drug discovery and chemical biology. The position is based in the Department of Chemistry in Istanbul, Türkiye. The successful candidate will contribute to advancing machine-learning–identified targets and small-molecule hits toward validated chemical probes and early lead compounds.
Job Overview
The lab integrates machine learning, structural biology, chemical proteomics, and biophysical assays to identify and characterize novel drug-binding sites across challenging protein targets. The postdoctoral researcher will play a central role in translating computational predictions into experimentally validated molecules and targets through iterative design–make–test cycles. The lab is currently establishing new capabilities in chemical biology and protein target validation, and the successful candidate will have the opportunity to help shape early-stage research directions.
Important Dates
The anticipated start date for this position is Spring–Early Summer 2026 (flexible).
Eligibility Criteria
- Required Qualifications: PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or a related field.
- Strong skills in small-molecule synthesis and structure–activity relationship (SAR) analysis.
- Ability to design and execute experiments independently.
- Excellent analytical, communication, and teamwork skills.
- Preferred Skills: Experience with protein expression and purification.
- Familiarity with biochemical or biophysical assays.
- Interest in structure-based drug design or covalent inhibitors.
- Experience working in interdisciplinary environments combining chemistry, biology, and computation.
- Candidates with strong synthetic chemistry backgrounds but limited biological experience are encouraged to apply; training in relevant biochemical and structural techniques will be provided.
Job Responsibilities
- Design and synthesize novel small molecules guided by machine learning predictions and structural biology.
- Conduct structure–activity relationship (SAR) studies and lead optimization campaigns.
- Express and purify recombinant proteins for biochemical characterization.
- Perform protein–ligand interaction assays (e.g., enzymatic assays, FP, DSF).
- Collaborate with computational and experimental teams to support iterative design–make–test cycles.
- Contribute to manuscripts, conference presentations, and collaborative research projects.
Compensation and Location
The location for this position is Boğaziçi University, Istanbul, Türkiye. Salary and benefits follow Boğaziçi University postdoctoral fellowship guidelines and are competitive with international postdoctoral research positions.
How to Apply
Interested candidates should send their Curriculum vitae, a brief research statement (optional but encouraged), and contact information for three references to Dr. Fettah Erdoğan via email at [email protected].
Conclusion
Eligible candidates interested in this postdoctoral researcher opportunity in AI drug discovery and chemical biology at Boğaziçi University are encouraged to apply following the instructions above.
